Here are some selected abstracts of publications, with links to their full text:
The Journal of the American Medical Association – Psychiatry (2021)
Association of Brain Reward Response With Body Mass Index and Ventral Striatal-Hypothalamic Circuitry Among Young Women With Eating Disorders. Guido K.W. Frank, MD; Megan E. Shott, BS; Joel Stoddard, MD; Skylar Swindle, BS; Tamara L. Pryor, PhD.
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Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (2021)
Persistence, Reward Dependence, and Sensitivity to Reward Are Associated With Unexpected Salience Response in Girls but Not in Adult Women: Implications for Psychiatric Vulnerabilities. Guido K.W. Frank, Megan E. Shott, Lot C. Sternheim, Skylar Swindle, and Tamara L. Pryor.
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The Journal of the American Medical Association – Psychiatry (2018)
Association of Brain Reward Learning Response with Harm Avoidance, Weight Gain, and Hypothalamic Effective Connectivity in Adolescent Anorexia Nervosa. Guido Frank, Marisa DeGuzman, Megan Shott, Mark Laudenslager, Brogan Rossi, Tamara Pryor
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Transitional Psychology (2016)
Altered Structural and Effective Connectivity in Anorexia and Bulimia Nervosa in Circuits that Regulate Energy and Reward Homeostasis. Guido Frank, Megan Shott, Justin Riederer, Tamara Pryor
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CNS Drugs: Drug Therapy in Neurobiology and Psychiatry (Springer, 2016)
The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects. Guido K. W. Frank & Megan E. Shott
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Journal of International Psychiatry (2016)
Extremes of Eating are Associated with Reduced Neural Taste Discrimination. Guido K.W. Frank, Megan E. Shott, Carrie Keffler, & Marc-Andre Cornier
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Neuropsychopharmacology (2015)
Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa. Megan E. Shott, Tamara L. Pryor, Tony T. Yang, and Guido K.W. Frank
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International Journal of Obesity (2014)
Orbitofrontal Cortex Volume and Brain Reward Response in Obesity. M.E. Shott, M.A. Cornier, V.A. Mittal, T.L. Pryor, M.S. Brown and Guido K.W. Frank
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American Journal of Psychiatry (2013)
Alterations in Brain Structures Related to Taste Reward Circuitry in Ill and Recovered Anorexia Nervosa and in Bulimia Nervosa. Guido K. Frank, Megan E. Shott, Jennifer O. Hagman & Vijay A. Mittal
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Current Psychiatry Report (2013)
Altered Brain Reward Circuits in Eating Disorders: Chicken or Egg? Guido K.W. Frank
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International Journal of Eating Disorders (2013)
White Matter Integrity is Reduced in Bulimia Nervosa. Lisa N. Mettler, Megan E. Shott, Tamara Pryor, Tony T. Yang & Guido K.W. Frank
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Neuropharmacology (2012)
Anorexia Nervosa and Obesity are Associated with Opposite Brain Reward Response. Guido K.W. Frank, Jeremy R. Reynolds, Megan E. Shott, Leah Jappe, Tony T. Yang, Jason R. Tregellas, & Randall C. O’Reilly
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Wiley Online Library (2012)
Cognitive Set-Shifting in Anorexia Nervosa. Megan E. Shott, J. Vincent Filoteo, Kelly A.C. Bhatnagar, Nicole J. Peak, Jennifer O. Hagman, Roxanne Rockwell, Walter H. Kaye & Guido K.W. Frank
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Neuropsycology (2012)
Altered Implicit Category Learning in Anorexia Nervosa. Megan E. Shott, J. Vincent Filoteo, Leah M. Jappe, Tamara Pryor, W. Todd Maddox, Michael D. H. Rollin, Jennifer O. Hagman, & Guido K. W. Frank
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Journal of Biological Psychiatry (2011)
Altered Temporal Difference Learning in Bulimia Nervosa. Guido K.W. Frank, Jeremy R. Reynolds, Megan E. Shott, and Randall C. O’Reilly
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International Journal of Eating Disorders (2011)
Heightened Fear of Uncertainty in Anorexia and Bulimia Nervosa. Guido K.W. Frank, Tami Roblek, Megan E. Shott, Leah M. Jappe, Michael D.H. Rollin, Jennifer O. Hagman, Tamara Pryor
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Psychiatry Research: Neuroimaging (2011)
Altered Fimbria-Fornix White Matter Integrity in Anorexia Nervosa Predicts Harm Avoidance. Demitry Kazlouski, Michael D.H. Rollin, Jason Tregellas, Megan E. Shott, Leah M. Jappe, Jennifer O. Hagman, Tamara Pryor, Tony T. Yang, Guido K.W. Frank
Click here to read the article
International Journal of Eating Disorders (2011)
Heightened Sensitivity to Reward and Punishment in Anorexia Nervosa. Leah M. Jappe, Guido K.W. Frank, Megan E. Shott, Michael D.H. Rollin, Tamara Pryor, Jennifer O. Hagman, Tony T. Yang, Elizabeth Davis
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Developmental Brain Research Focused on Eating Disorders
Anorexia (AN) and Bulimia Nervosa (BN) are severe psychiatric disorders that most commonly begin during adolescence – which is a critical period of significant change in both biological and psychosocial development. Neurobiological and genetic factors have only recently been recognized as contributing to the development of AN and BN, in addition to well-known psychological and environmental factors. This new understanding of the etiology of eating disorders (ED) lays the foundation for a developmental neuroscience perspective in ED research.
“Brain imaging provides a window into the living human brain and may help us understand mechanisms that cause eating disorders. Only if we know how the brain works differently in eating disorders then we can work to improve treatment and make recovery more successful.” Guido Frank, MD., FAED
The Know Your Client/Know Your Patient Project
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